Chicago Bears vs Carolina Panthers
1:00 PM ET | FOX
Caleb Williams — Anytime Touchdown
Carolina struggled against the run last season and was near the bottom of the NFL in rushing touchdowns allowed. Williams gives Chicago another goal-line threat outside of its running backs, especially when plays break down.Jalen Coker — 39+ Receiving Yards
Coker cleared this number in five of his final seven games last season and four of his final five. His work from the slot should also give him favorable opportunities against Chicago.
Baltimore Ravens vs Indianapolis Colts
1:00 PM ET | CBS
Lamar Jackson — 40+ Rushing Yards
Indianapolis has to respect Derrick Henry between the tackles, which should create opportunities for Lamar on the outside. Designed runs mixed with his scrambling ability give him a strong chance to reach 40 yards.Ja'Kobi Lane — 18+ Receiving Yards
This is a low number for a receiver who should have opportunities underneath. Baltimore has plenty of weapons drawing attention elsewhere, meaning Lane only needs one or two solid catches.
Atlanta Falcons vs Pittsburgh Steelers
1:00 PM ET | CBS
Aaron Rodgers — 200+ Passing Yards
Pittsburgh should still lean heavily on the run, but Rodgers doesn't need massive volume to reach 200. The addition of DK Metcalf also gives him a legitimate deep threat.Pat Freiermuth — Anytime Touchdown
Freiermuth should remain one of Rodgers' primary red-zone options. Pittsburgh also uses plenty of multiple-tight-end formations, keeping him on the field in scoring situations.
Cleveland Browns vs Jacksonville Jaguars
1:00 PM ET | CBS
Trevor Lawrence — 225+ Passing Yards
Lawrence's market is sitting above this number, so I like taking the safer 225-yard milestone. Jacksonville should move the ball early and give Lawrence enough passing volume to get there.Parker Washington — 50+ Receiving Yards
Washington flashed serious upside late last season with multiple 70+ yard performances. If Lawrence has a strong afternoon, Washington should be heavily involved.
Tampa Bay Buccaneers vs Cincinnati Bengals
1:00 PM ET | FOX
Baker Mayfield — 230+ Passing Yards
Cincinnati allowed 245.1 passing yards per game to quarterbacks last season. Tampa Bay could also be playing from behind, which would keep Baker throwing throughout the second half.Joe Burrow — 2+ Passing Touchdowns
This is one of the highest projected scoring games of the day. If Cincinnati reaches the 25-30 point range, I expect Burrow to account for multiple touchdowns through the air.Emeka Egbuka — Anytime Touchdown
Egbuka should remain heavily involved around the red zone. In a game I expect to have plenty of scoring, I like his chances of finding the end zone.
New York Jets vs Tennessee Titans
1:00 PM ET | CBS
Braelon Allen — 18+ Rushing Yards
This should be one of the more run-heavy games today. Allen only needs a handful of carries to clear this number and should have a role behind Breece Hall.Gunnar Helm — Anytime Touchdown
This is one of my longer-shot picks. The Jets ranked near the bottom of the league defending tight ends last season, making Helm an interesting red-zone option.
New Orleans Saints vs Detroit Lions
1:00 PM ET | FOX
Jahmyr Gibbs — 80+ Rushing Yards
Detroit should control this game, which gives Gibbs exactly the game script I want. If Detroit is playing with a lead in the second half, his rushing attempts should continue piling up.Jameson Williams — Anytime Touchdown
Williams can change the game with one play. His speed makes him dangerous every time Detroit takes a shot downfield, and I expect the Lions to create plenty of scoring opportunities.Jared Goff — 275+ Passing Yards
I have Goff going over 300 yards in my game prediction, but 275 gives us a safer number. With Amon-Ra St. Brown, Williams, Sam LaPorta and Gibbs around him, Goff has everything he needs for a big Week 1.
Buffalo Bills vs Houston Texans
1:00 PM ET | CBS
Josh Allen — 2+ Passing Touchdowns
Houston has an elite defense, but Allen has thrown at least 25 touchdowns in six straight seasons. Buffalo adding DJ Moore gives him another explosive weapon to work with.Josh Allen — 30+ Rushing Yards
Houston's secondary could force Allen to hold onto the football longer and leave the pocket. Once that happens, Allen remains one of the most dangerous rushing quarterbacks in football.
Arizona Cardinals vs Los Angeles Chargers
4:25 PM ET | CBS
Trey McBride — 7+ Receptions
McBride has become one of the highest-volume tight ends in football. Arizona could also be playing from behind, which would increase his opportunities throughout the second half.Trey McBride — Anytime Touchdown
McBride is Arizona's biggest mismatch in the passing game and should be one of their first options near the goal line.Ladd McConkey — 60+ Receiving Yards
McConkey remains one of Justin Herbert's most reliable targets. With Los Angeles expected to score plenty of points, I like McConkey to get enough volume to clear 60.
Green Bay Packers vs Minnesota Vikings
4:25 PM ET | FOX
Justin Jefferson — 75+ Receiving Yards
Jefferson has consistently commanded one of the highest target shares in football. I expect Minnesota to get him involved immediately and give him enough volume to reach 75 yards.Justin Jefferson — Anytime Touchdown
Minnesota has Kyler Murray at quarterback, but Jefferson remains the centerpiece of this passing attack. Once Minnesota reaches the red zone, Jefferson is still option No. 1.Jordan Love — 225+ Passing Yards
I expect this game to stay competitive into the fourth quarter. That should keep Green Bay throwing and give Love enough attempts to clear a manageable 225-yard number.
Miami Dolphins vs Las Vegas Raiders
4:25 PM ET | CBS
Kirk Cousins — 200+ Passing Yards
If Miami gets ahead, Las Vegas will have to move away from its running game. Cousins should have enough attempts to reach 200 even if the Raiders offense struggles to score.Jack Bech — 40+ Receiving Yards
With Brock Bowers unavailable, additional targets have to go somewhere. Bech should have opportunities across the middle and only needs a few catches to reach 40.
Washington Commanders vs Philadelphia Eagles
4:25 PM ET | FOX
Jalen Hurts — 225+ Passing Yards
Philadelphia no longer has A.J. Brown, but Hurts still has DeVonta Smith and Dallas Goedert. Washington should keep this competitive enough that Philadelphia can't completely abandon the pass.Jalen Hurts — Anytime Touchdown
Hurts remains one of the safest quarterback touchdown threats in football because of Philadelphia's short-yardage offense.Dallas Goedert — Anytime Touchdown
With Brown gone, Goedert should become even more important around the red zone. I like his chances of seeing multiple scoring opportunities.
Dallas Cowboys vs New York Giants
8:20 PM ET | NBC / Peacock
Dak Prescott — 250+ Passing Yards
Dallas finished second in total offense last season at 391.9 yards per game. With CeeDee Lamb and George Pickens available, I expect Dallas to come out throwing.CeeDee Lamb — Anytime Touchdown
Lamb remains one of Dak's most important targets, especially on third down and inside the red zone. In a game projected near 50 total points, I want Lamb involved in the touchdown market.George Pickens — Anytime Touchdown
Lamb demands so much defensive attention that Pickens should see favorable one-on-one opportunities. One deep ball or red-zone target could be enough to cash this.